United States Patent (6,361,807 B1, issued September 21, 1999): Michael Aviram, Leslie Dornfeld. Pomegranate extracts and methods of using thereof.7 The patent provides antioxidative compositions comprising an extract from pomegranate fruit. Antioxidative compositions for treating disorders associated with lipoprotein oxidation, lipoprotein aggregation, macrophage atherogenicity, platelet activation, or atherosclerosis are also provided. (Note: US Patents 6,375,993 B1 [August 23, 2002] and 6,387,418 B1 [May 14, 2002] are continuations of US Patent 6,361,807 B1).
United States Patent (6,641,850 B1, issued November 4, 2003): Michael Aviram, Leslie Dornfeld. Methods of using pomegranate extracts for causing regression in lesions due to atherosclerosis in humans.8 Patent provides methods of administering pomegranate extracts for treating patients with atherosclerosis or intima-media thickness of an artery. The methods comprise the step of administering to the patient a composition comprising a therapeutically effective amount of an extract from pomegranate. The invention also provides methods of decreasing the incidence of stroke or heart attack in a patient by administering to the patient a composition comprising a therapeutically effective amount of an extract from pomegranate. (Note: US Patent 6,977,089 B1 [December 20, 2005] is a continuation of US Patent 6,641,850 B1).