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DOSAGE AND DURATION OF ADMINISTRATION

DOSAGE AND DURATION OF ADMINISTRATION

Various curcumin preparations have been shown to be well-tolerated in humans at doses of up to 12 g per day.3,24 The dose of BCM-95 used in three clinical studies was 500 mg twice daily for a total of 1 g per day.25-28 Other clinical studies with BCM-95 used daily doses up to 4 g.29-34

BCM-95 is available in softgel capsules supplying either 250 mg or 500 mg curcuminoids. BCM-95 is also available in preparations in which it is combined with other ingredients (Table 2).

There are no data that suggest a limitation on the duration of use for turmeric or its primary constituent curcumin in varying amounts, based on use of turmeric as a traditional food and medicine. BCM-95 has been administered daily in clinical studies for periods of eight weeks to six months without any serious adverse events (see Human Clinical Trials and Safety sections below).