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DESCRIPTION OF BCM-95

DESCRIPTION OF BCM-95 (CURCUGREEN)

BCM-95 (Curcugreen), originally named Biocurcumax™ (hence, the acronym ”BCM”), is a unique preparation of standardized curcuminoids that is blended with the essential oil of turmeric. BCM-95 is formulated by Arjuna Natural Extracts Ltd. of Alwaye, Kerala, India (see Patents section below).

BCM-95 is prepared from turmeric rhizomes, using a proprietary standardized process. The turmeric is grown without herbicides or pesticides in the traditional manner in Assam, a remote area of northeast India. The rhizomes are dried in sunlight, powdered, and treated with a food-grade extraction solvent* (ethyl acetate and ethanol) to concentrate the curcuminoids. Following extraction, the solvent is removed according to procedures and standards set by the United States Pharmacopeia (USP). The raw material and finished goods are analyzed for any level of contamination with class 1, 2a, and 2b solvents, even though none of these is used in the extraction process. The resultant concentrate is cooled, resulting in the formation of crystals of curcuminoids. The volatile oil (essential oil) of turmeric is isolated from dried turmeric rhizomes by steam distillation. The curcuminoids and the volatile oil are blended together into a slurry using filtered and distilled water. The water is removed under low heat and high vacuum to form a uniform blend. The final herb-to-extract ratio is 25:1. The powder has an orange-red color. The shelf-life of the extract is 36 months when stored in a cool and dry environment. Stability studies conducted at 30°C and 65% humidity for 36 months according to ICH (International Council on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use) guidelines Q1A(R2)11 did not show any deterioration of physical, chemical, or microbial parameters.

BCM-95 contains a 95% curcuminoid complex composed of curcumin, demethoxycurcumin, and bisdemethoxycurcumin, in their natural ratios, along with turmeric essential oil. After the addition of the essential oil, BCM-95 contains no less than 86% total curcuminoids and 65% curcumin. The essential oil contains approximately 45% ar-turmerone.