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Scientific Name:
Lavandula angustifolia (syn. L. officinalis, L. vera, L. spica) ± subsp. pyrenaica
Family Name:
Common Name:
English, common lavender
Evidence of Activity
Animal Studies
Oral adminisration of Lavandula angustifolia combined with Bacopa monnieri and Ginkgo biloba reduced mouse escape latency and accumulative path length in acute (up to day 6) and chronic trials in mice. Synergistic effects on memory enhancement were observed compared to each extract individually. Rehman 2021
Essential oil from leaves of Lavandula officinalis protected adult mice from hydrogen peroxide-induced hepatic and renal injury. Sara 2020
Silexan, an essential oil from Lavandula angustifolia flowering tops, showed antidepressant activity in a rat model similarly to imipramine, and induced neurite outgrowth and synaptogenesis in neuronal cell models, including primary hippocampal neurons. Friedland 2020
Silexan®, a proprietary Lavandula angustifolia flower essential oil product, exhibits anxiolytic and antidepressant effects via inhibition of voltage dependent calcium channels and improvement of neuroplasticity, respectively, with the involvement of intracellular signaling kinases PKA and MAPK. Müller 2020
Topical application of Lavandula angustifolia essential oil (2%-10%) induced up to 73.67% recovery of psoriasis severity, being slightly irritant at the higher dose, by normalizing the levels of Th-17 cell-specific cytokines, in BALB/c mice. Rai 2020
Inhalation of Lavandula angustifolia essential oil (1%, but not 2.5% or 5%) enhanced extinction learning and inhibited memory updating in adult male C57Bl6 mice submitted to fear conditioning. Manganiello-Terra 2020
Aqueous extract of Lavandula officinalis (syn. Lavandula angustifolia) decreased serum cholesterol levels and prevented fat accumulation in the livers of mature female BALB/c mice on a high-fat diet. Hosseini 2020
A topical nanoemulsion cream containing lavender (Lavandula angustifolia) essential oil and a licorice (Glycyrrhiza glabra) extract promoted the healing of deep excision skin wounds in rats. Kazemi 2020
Acute oral administration of Lavandula angustifolia essential oil (100 mg/kg) alleviated neuropathic pain induced by a spared nerve injury, in mice, with the involvement of the endocannabinoid system. Sanna 2019
Aromatherapy with Lavandula angustifolia essential oil induced a calming effect in horses in a crossover study. Baldwin 2018
Lavandula angustifolia oil (50-200 mg/kg, i.p.) restored activities of antioxidant enzymes and reduced lipid peroxidation and levels of pro-inflammatory cytokines, while preserving the morphology of kidney cells in a rat model of renal ischemia/reperfusion. Aboutaleb 2018
Lavandula angustifolia essential oil (200 mg/kg) or its main constituent linalool (100 mg/kg), administered intraperitoneally, reduced social aversion and anxiety induced by social defeat in mice. Caputo 2018
Intraperitoneal administration of lavender (L. angustifolia) essential oil (100-300 mg/kg) immediately following ischemia reduced markers of cardiac injury in a rat model of myocardial infarction. Souri 2018
Lavender (L. angustifolia) oil was more effective than ibuprofen in ameliorating stress-induced behavioral and biochemical alterations in rats. Qadeer 2018
Linalool, a major component of L. angustifolia, significantly ameliorated the spatial and learning memory deficits, and stress activity observed in sleep-deprived in mice. It also led to serotonin release, and cortisol level reduction. Lee 2018
Levels of 10 metabolite markers including alanine, glutamine, serine, isoleucine, valine, carnitine, isobutyrate, pantothenate, glucose and asparagine were reversed nearly to control values after treatment with aqueous L. angustifolia extract in a rat model of Alzheimer's disease. Oskouie 2018
Topical application of Lavandula angustifolia essential oil reduced edema formation, myeloperoxidase activity, and nitric oxide production, croton oil-, carrageenan-, and dextran-induced edema models, in vivo, thus presenting anti-inflammatory effects. Cardia 2018
Inhaling Lavandula angustifolia essential oil inhibited consolidation of contextual fear conditioning in rats, and correlated with decreased c-Fos expression in the ventral hippocampus and amygdala. Coelho 2018
Lavender (L. angustifolia) essential oil (100 mg/kg) curtailed cognitive impairment induced by D-galactose and aluminum trichloride, by rescuing antioxidant enzyme systems, cholinergic function, and hippocampal synaptic plasticity, in mice. Xu 2017
A hydroalcoholic extract of Lavandula officinalis aerial parts improved scopolamine-induced memory impairment and reduced anxiety and depression-like behaviour in several rat models. Rahmati 2017
A combination of essential oils of Rosa damascena and Lavandula angustifolia alleviated oxidative toxicity of levodopa (L-dopa) in mice. Nikolova 2016
Lavender (Lavandula angustifolia) essential oil (100mg/kg) ameliorated cognitive decline induced by scopolamine in an Alzheimer's disease model, in mice. It significantly decreased the AChE activity, MDA level, and increase SOD and GPX activities of the model. Xu 2016
A combination of Rosa damascena (rose) and Lavandula angustifolia essential oils, vitamin C, and Trolox reduced the oxidative toxicity of L-dopa in healthy mice. Nikolova 2016
An extract of Lavandula angustifolia (200-400 mg/kg) restored structural and functional neural integrity, as shown by sensory tests, EMG, and staining for lesions, in a rat model of spinal cord injury. Kaka 2016
Lavender angustifolia essential oil, as well as its constituents linalool and linalyl acetate, induced apoptosis in 74.76% of the PC-3 human prostate cancer cells in vitro, and suppressed the tumor growth in mouse xenografts. Zhao 2016
Application of a Lavandula angustifolia extract greatly improved the effectiveness of human umbilical mesenchymal stem cell transplantation in rats with spinal cord injury. Yaghoobi 2016
An aqueous extract of Lavandula angustifolia restored deteriorated synaptic plasticity in an animal model of Alzheimer's disease. Soheili
A hydroalcoholic extract of Lavandula angustifolia, administered orally at 200, 400 and 800 mg/kg prior to pentobarbital injection, shortened sleep onset by 7.6%, 50% and 51.5% and prolonged sleep duration by 9.9%, 43.1% and 80.2%, respectively, in mice. Hajhashemi 2015
L. angustifolia (LA) extract improved the spatial performance in Alzheimer's disease rat model by diminishing beta-amyloid production in histopathology of hippocampus. Neuroprotective proteins expressed in hippocampus in response to effective components in LA were explored as potential drug targets. Zali 2015
Lavandula angustifolia essential oil, administered i.p., showed cardioprotective effects in rats with isoproterenol-induced myocardial infarction. Ziaee 2015
The effects of Lavandula officinalis essential oil on rumen fermentation characteristics, methane production and ruminal acidosis were studied in vitro. Yadeghari 2015
An ethanolic extract of Lavandula officinalis decreased serum cholesterol, triglyceride, LDL, VLDL, and increased HDL levels, in rats. Rabiei 2014
An ethanolic extract of Lavandula officinalis, injected i.p., significantly reduced the blood-brain barrier permeability in a brain-ischemia model in rats. Rabiei 2014
Inhalation of Lavandula angustifolia (syn. L. officinalis) essential oil produced anxiolytic-like effects in mice, independent of the olfactory perception, and increased the striatal and hippocampal levels of serotonin, via decreasing its turnover, in accordance with the effects. Takahashi 2014
20 dogs affected by dermatitis due to M. pachydermatis were given a mixture of essential oils including L. officinalis in the product Malacalm® or a conventional therapy. After 180 days dogs treated with the conventional therapy had a return of symptoms while the Malacalm® treated dogs did not. Nardoni 2014
Focal cerebral ischemia was induced in rats and lavender oil was injected at the onset of ischemia. Treatment with lavender oil at doses of 200 and 400 mg/kg significantly diminished infarct size, brain edema, and improved functional outcome after cerebral ischemia. Vakili 2013
Silexan, an essential oil product from L. angustifolia ( 3-30 mg/kg i.p.) produced almost exclusively saline-like responding in rats trained to discriminate the benzodiazepine drug diazepam (2 mg/kg i.p.) from saline, suggesting Silexan has no diazepam-like interoceptive property in adult male rats. Silenieks 2013
In a scopolamine-induced dementia rat model, inhaled lavender essential oils, including L. angustifolia showed potent antioxidant and antiapoptotic activities. Hancianu 2013
All the 3 doses of Silexan (3, 10, and 30 mg/kg i.p.), an essential oil produced from L. angustifolia flowers, showed significant & dose-dependent anxiolytic activity in the used pharmacological models in rats & mice, which was comparable to that of the standard anxiolytic agent lorazepam. Kumar 2013
On farms, separate groups of 10 donkeys sprayed with 5% (v/v) tea tree and L. angustifolia essential oil as part of their usual grooming regime showed significant reductions in B. ocellatus louse numbers compared with a control group. Ellse 2013
Two behavioral tests indicated that inhalation of L. angustifolia by mice finding that serotonergic but not GABAA/benzodiazepine neurotransmission participates in the anxiolytic-like effect of lavender essential oil inhalation in mice. Chioca 2013
Anosmia did not interfere with the anxiolytic-like effect of L.angustifolia essential oil inhaled in the marble-burying test at concentrations of 2.5% and 5%. Lavender essential oil at a concentration of 0.5% was ineffective, suggesting olfactory system activation is not necessary for these effects. Chioca 2013
L. officinalis was more effective than Valproate in reducing seizure score of kindled mice and PTZ-induced mortality. L. officinalis suppressed nitric oxide level more than Valproate and L. officinalis also decreased brain MDA level relative to PTZ group. Rahmati 2013
Out of 20 essential oils tested for insecticide abilities, Lavandula angustifolia at a 10% concentration was one of the most effective in a susceptibility test against the housefly species Musca domestica L. Sinthusiri 2013
After i.p. pentylenetetrazol injection, Balb-c mice from 8 different groups, each treated with a different essential oil (including L. angustifolia), showed increased latency and reduced severity of seizures. Mice who had received M. piperita demonstrated no seizures and 100% survival. Koutroumanidou 2013
Among transcutaneous electrical nerve stimulation (TENS), saline solution, povidone-iodine, and L. angustifolia oil used to heal wounds in a rat model, TENS and lavender oil were found to produce quicker results in wound closure. Koca Kutlu 2013
Inhalation of a Lavandula officinalis (syn. L. angustifolia) essential oil showed anxiolytic-like effects in stressed mice, while possibly inducing a stress response in stress-free animals. Takahashi 2012
Study of mice in battery of behavioural models found methanolic and aqueous extracts of Lavandula officinalis possess potent sedative and hypnotic activities, which supports therapeutic use of lavender for insomnia. Alnamer 2012
In rats with scopolamine (0.7mg/kg)-induced dementia, multiple exposures (inhalation) to lavender essential oils effectively reverse spatial memory deficits induced by dysfunction of the cholinergic system in the rat brain suggesting potential therapies for dementia & other neurological conditions. Hritcu 2012
L. angustifolia oil significantly decreased neurological deficit scores, infarct size, the levels of MDA, carbonyl & ROS, & attenuated neuronal damage, as well as other beneficial activities in cerebral ischemia/reperfusion injury in mice. Wang 2012
Mice induced with chemoconvulsant seizures given an extract of Lavandula officinalis showed anticonvulsant activity with the most effective dose at 600 mg kg(-1). Arzi 2011
Aqueous extract of L. angustifolia (100 and 200 mg/kg) effectively reversed spatial learning disabilities in both control animals and male Wistar rats with Alzheimer's disease. Kashani 2011
The antidepressant effects of essential oils of Anthemis nobilis (chamomile), Salvia sclarea (clary sage; clary), Rosmarinus officinalis (rosemary), and Lavandula angustifolia (lavender) were assessed using a forced swim test (FST) in rats. Seol 2010
Lavandula angustifolia was effective in controlling Rhipicephalus (Boophilus) annulatus ticks in vitro. Pirali-Kheirabadi 2010
Laboratory bioassays on insecticidal activity of essential oils (EOs) extracted from six Mediterranean plants including L. angustifolia against the mosquito Aedes albopictus found that at 300ppm L. angustifolia produced a 55% rate of mortality. Conti 2010
Female Mongolian gerbils receiving lavender odor inhalation from Lavandula angustifolia over 2 weeks exhibited similar reduction in anxiety as exhibited with the drug diazepam. In addition lavender exposure in this sex increased exploratory behavior, another sign of decreased anxiety. Bradley 2007
Lavandula angustifolia essential oil in concentrations of 5, 10 and 20% v/v. showed repellent effects against adult ticks Hyalomma marginatum rufipes and compared well with DEET for the 2 hour period of study. Mkolo 2007
The traditional use of Lavandula angustifolia for the treatment of painful and inflammatory conditions was confirmed in mice using formalin and acetic acid-induced writhing tests. Hajhashemi 2003
Rabbit conjunctival reflex and contractions of rat phrenic-hemidiaphragm are decreased, dose-dependently, by L. angustifolia essential oil, linalyl acetate and linanol. Ghelardini 1999
The essential oil of Lavandula angustifolia, as well as its constituents, showed sedative effects upon inhalation, in mice. Buchbauer 1991
Sedative effects by essential oil of Lavandula angustifolia diluted 1/60 in olive oil, given orally in mice. Sleeping time is increased and waking time shortened. [Article in French] Guillemain 1989
History of Record
LATEST UPDATES BY: Bernard Somers, BS, PhD candidate
April 2021