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Scientific Name:
Harpagophytum procumbens, H. zeyheri
Family Name:
Pedaliaceae
Common Name:
devil's claw, grapple plant, wood spider
Evidence of Activity
Pharmacokinetics (ADME)
Cat's claw (H. procumbens), peppermint oil and Siberian eleuthero inhibited CYP3A4 activity more potently than 0.1 μM ketoconazole in fAd-CYP3A4 cells (frozen recombinant P450-expressing cells infected with human CYP3A4 expressing adenovirus). Sato 2015
It is demonstrated for the first time that devil's claw may interact with the multidrug transporter ABCB1/P-gp, the effect not appearing strictly related to the harpagoside relative content. Romiti 2009
History of Record
ORIGINAL RESEARCH BY: J. Mohanasundaram, MD, PhD
June 2006
MAJOR REVISION BY: Eli Scheinman, MES
January 2018
LATEST UPDATES BY: Oren Rabinowitz, MSc
October 2021