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Milk Thistle fruit
Cardui mariae fructus
Mariendistelfrchte
Published March 13, 1986;
Name of Drug

Cardui mariae fructus, milk thistle fruit.  

Composition of Drug

Milk thistle fruit consists of ripe seed of Silybum marianum (L.) Gaertner [Fam.  Asteraceae], freed from the pappus, and its preparations in effective dosage.  

The drug contains silibinin, silydianin, and silychristin.  

Crude drug:

  • Dyspeptic complaints.  

Formulations:*

  • Toxic liver damage; for supportive treatment in chronic inflammatory liver disease and hepatic cirrhosis.  

Contraindications

None known.  

Side Effects

Crude drug:

  • None known.  

Formulations:

  • A mild laxative effect has been observed in occasional instances.  

Interactions with Other Drugs
Dosage

Unless otherwise prescribed:

Average daily dose of drug:

  • 12 - 15 g;
  • Formulations equivalent to 200 - 400 mg of silymarin, calculated as silibinin.  

Mode of Administration

Powdered drug for making infusions and other galenical formulations to be taken by mouth.  

Actions

Silymarin acts as an antagonist in many experimental liver-damage models: phalloidin and -amanitin (death-cap toxins), lanthanides, carbon tetrachloride, galactosamine, thioacetamide, and the hepatotoxic virus FV3 of cold-blooded vertebrates.  

The therapeutic activity of silymarin is based on two sites or mechanisms of action:

(a) it alters the structure of the outer cell membrane of the hepatocytes in such a way as to prevent penetration of the liver toxin into the interior of the cell;

(b) it stimulates the action of nucleolar polymerase A, resulting in an increase in ribosomal protein synthesis, and thus stimulates the regenerative ability of the liver and the formation of new hepatocytes.  

*[Ed.  note:"Formulation" refers to an extract standardized to at least 70 percent silymarin, the collective name for the three compounds listed in the

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Dyspepsia
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Hepatoprotective
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